FORMULATION OF 70% ETHANOL EXTRACT OINTMENT OF KECAPI LEAVES (Sandoricum koetjape) AND ANTIBACTERIAL ACTIVITY TEST AGAINST Staphylococcus aureus BACTERIA

Abstract

Background: Kecapi’s leaves are one part of a plant that thrives in Indonesia. Kecapi’s leaves are known to have secondary metabolites such as alkaloids, flavonoids, tannins and terpenoids. These compounds can inhibit bacterial growth. 

Purpose: This research aims to formulate kecapi’s leaf extract with concentrations of 5%, 10%, and 15% to become an ointment and tested on the bacteria Staphylococcus aureus. 

Methodology: The method used in the antibacterial test uses the agar well diffusion method. 

Results:These results showed that kecapi leaf extract ointment had antibacterial activity and the largest inhibition zone was in the 15% concentration ointment with an average inhibition zone of 8.3 mm (medium category). Antibacterial test results data were tested using the Kruskal-Wallis with a value of 0.010 (p <0.05) which stated that the ointment preparations with various concentrations had significant differences. The results of data processing were continued with the Mann-Whitney test and it was found that the negative control and positives control had significant differences with the other samples.